↑transaminases, thrombocytosis, ↓IgA, ↓IgG, ↓Cu, ↓Fe, ↓Zn, ↓cholesterol, ↓albumin, ↓Factor XI, ↓antithrombin III, abnormal TIFT (type 1 pattern), proteinuria, prolonged prothrombin time, hypergonadotropic hypogonadism, hypothyroidism. This evidence concerns the gene F2 and Hypergonadotropic hypogonadism.