The only larger cohort, Latin American Research Consortium on the Genetics of PD (LARGE-PD, PI Dr. Mata) consisting of 1,150 Latino patients originating from southern South America, reports an enrichment of a novel variant in PD gene LRRK2 (p.Q1111H, rs78365431) in Peruvian and Chilean PD patients and controls (27) as well as a GBA mutation (p.K237E, rs773409311) in Colombian patients only (28), suggesting these variants originated from the Amerindian genetic background in these patients. Here, LRRK2 is linked to Parkinson disease.