VCAM1 and neoplasm: The effects of NO on adhesion protein expression not only affect tumor cell adhesion at the metastatic site but also infiltration of immune cells in the primary tumor, where it has been demonstrated that NO, produced by iNOS in M1 macrophages, mediates VCAM-1 expression in the endothelium leading to an improved infiltration of T-lymphocytes specific for the tumor, contributing to decrease tumor growth in a mouse melanoma model (Sektioglu et al., 2016).