HIF1A and neoplasm: Additionally, another transcription factor, HIF-1α expressed in endothelial cells, is involved in extravasation of breast cancer cells through the expression of L1CAM adhesion protein that binds to tumor cells, and HIF-1α has been demonstrated to be activated by S-nitrosylation in others cellular contexts (Li et al., 2007; Zhang et al., 2012; Ehrenfeld et al., 2019).