PRKG1 and heart failure: The cardioprotective abilities of PKG have been demonstrated in the setting of various cardiac diseases including PO, MI, ischemia/reperfusion injury and is the subject of many clinical trials as a heart failure treatment (Kokkonen-Simon et al., 2018; Dunkerly-Eyring and Kass, 2019; Pinilla-Vera et al., 2019; Oeing et al., 2020b).