Initially inactive and distant from the tumor bed, DCs become active (denoted by aDC) after the stimulation of purinergic receptors upon tumor-derived extracellular ATP binding (mainly the high-affinity metabotropic P2Y2R and the low-affinity ionotropic P2X7R; Rossi et al., 2012), which ignites the migratory status of the DC. Here, P2RY2 is linked to neoplasm.