CXCR3 is a chemotactic receptor on activated T cells, which binds CXCL10 released by tumor cells and by intratumoral activated DCs, following autocrine and paracrine stimulation by type-1 IFNs (Figure 3) (Zitvogel et al., 2015; Galluzzi et al., 2017). The gene discussed is CXCR3; the disease is neoplasm.