Because the local supply of free acetate in the nuclei of cells is generated via the action of protein deacetylases including histone deacetylases (HDACs), it seems likely that a major role for ACSS2 is the recycling of acetate produced through all deacetylation reactions, including those mediated by sirtuins, and this has recently been demonstrated in hypoxic cancer cells (Bulusu et al., 2017). Here, ACSS2 is linked to cancer.