Currently, the role of (pro)renin on the stimulation of distal Na+ reabsorption in hypertension is being actively investigated, particularly due to the presence of the (pro)renin receptor (PRR) in the CD (Advani et al., 2009; Gonzalez et al., 2011; Prieto et al., 2017). Here, ATP6AP2 is linked to hypertensive disorder.