USP14 and neoplasm: Both tumor-bearing mice and A549 cells displayed a panel of biomarkers based on autophagy and ferroptosis, such as upregulation of Beclin one and LC3II/LC3I, iron overload, lipid peroxidation, inhibition of USP14 activity and induction of the autophagy-related and ferroptosis-related proteins expression, supporting that USP14 is capable of regulating autophagy and ferroptosis.