Similarly, Indoprofene is a cyclooxygenase (COX) inhibitor, used as analgesic and anti-inflammatory drug (Paeile et al., 1989): it can increase SMN levels both in SMN2-luciferase cells and in type I SMA patient fibroblasts, and enhance the viability of a transgenic Type I SMA mouse model (Monani, 2000). Here, SMN1 is linked to spinal muscular atrophy, type 1.