SMN1 and neurodegenerative disease: This evidence suggests that ROCK inhibition can induce beneficial effects in SMA, as already demonstrated for several neurodegenerative diseases (Hensel et al., 2015), including SMA: indeed, Y-27632 and Fasudil are two RhoA/ROCK inhibitors, able to extend lifespan and improve motor functions in Taiwanese and SMN2B/− SMA mice (Bowerman et al., 2010; Bowerman et al., 2012; Bowerman, 2014; Hensel et al., 2017).