For example, Aclarubicin, an oligosaccharide anthracycline antineoplastic antibiotic, used in case of Acute Myeloid Leukemia treatment (Mitrou, 1990), was identified in 2001 via High-throughput screening on SMA type I fibroblast cell line and NSC-34 cell line containing SMN2 minigene reporter: Aclarubicin increases SMN2 exon seven inclusion, upregulating FL-SMN expression. Here, SMN1 is linked to acute myeloid leukemia.