This work aimed to explore the feasibility of using commercially-available human IPSC glutamatergic neurons as a tool to investigate neuronal structure and function concerning disease with direct application to understanding the influence of progranulin, a common causal genetic risk factor for FTD (Baker et al., 2006; Cruts et al., 2006) on relevant phenotypic endpoints. Here, GRN is linked to frontotemporal dementia.