During a characterization of the set of genes involved in Ca2+ signal generation differentially expressed in brain tumors and normal tissue, genes related to SOCE were found to be strongly perturbed, and one of the major actors of SOC, Orai 1, was disclosed as one of the genes whose expression is up-regulated in glioblastoma tissues and in GSCs (Robil et al., 2015). The gene discussed is UBXN11; the disease is glioblastoma.