Recently, a few genes known to play a role in cytoskeletal dynamics have been linked to ALS (Figure 1): alsin rho guanine nucleotide exchange factor (ALS2), dynactin subunit 1 (DCTN1), kinesin family member 5A (KIF5A), neurofilament light (NF-L), neurofilament heavy (NF-H), peripherin (PRPH), profilin 1 (PFN1), spastin (SPAST) and tubulin alpha 4a (TUBA4A). This evidence concerns the gene SPAST and amyotrophic lateral sclerosis.