However, the identification of several ALS-associated point mutations (Gros-Louis et al., 2004; Leung et al., 2004; Corrado et al., 2011) and a frameshift deletion (Gros-Louis et al., 2004) in PRPH raised the question as to whether these mutations are drivers of the ALS phenotype. The gene discussed is PRPH; the disease is amyotrophic lateral sclerosis.