SOD1 and amyotrophic lateral sclerosis: The list of ALS-related genes is continuously growing, however, SOD1, chromosome open reading frame 72 (C9orf72), TARDBP (transactive response DNA-binding protein) and FUS (fused in sarcoma) are the most well-studied, mainly because they account for the majority of both fALS and sALS cases (Brown and Al-Chalabi, 2017).