RCC1 and B-cell non-Hodgkin lymphoma: Alsin contains three domains that act as GTPase regulators (Hadano et al., 2001): (1) a regulator of chromosome condensation 1 (RCC1) like domain (termed RLD); (2) a diffuse B cell lymphoma (Dbl) homology/pleckstrin homology domain (termed DH/PH); and (3) a vacuolar protein sorting 9 domain (termed VPS9).