Aside from dysregulation of actin dynamics that disrupt axonal growth and promote growth cone arrest, PFN1 has been linked to other ALS features that include abnormalities in autophagy (Nguyen et al., 2019) and cytoplasmatic aggregations (Wu et al., 2012; Smith et al., 2015). Here, PFN1 is linked to amyotrophic lateral sclerosis.