Three major YAP signaling downstream genes, Ankrd1, Ctgf, and Cyr61, were upregulated, while genes encoding inhibitors of Yap translocation to the nucleus, Cdh1, Ctnna1, and Gsn, were detectable, but not passed our filter for DEGs (Figure 4P), indicating the involvement of Yap signaling in the initial phase of HC regeneration in chick BPs. This evidence concerns the gene CCN1 and Bartsocas-Papas syndrome 1.