NOX4 and cerebral palsy: The impairment of blood-brain barrier function after ICH can lead to the aggravation of persistent cerebral oedema (Keep et al., 2008; Urday et al., 2015; Mittal and LacKamp, 2016); thus, we measured the cerebral water content and found that NOX4 knockdown substantially reduced the cerebral water content in rats and alleviated the degree of oedema (Figure 5F).