Certainly, there is precedent for systemic dysregulation of HTRA-1 in preeclampsia though the precise changes relative to gestation as well as maternal and infant disease are not well elucidated owing to the paucity of data and variable GA assessments (Ajayi et al., 2008; Marzioni et al., 2012; Chen et al., 2014; Teoh et al., 2015; Liu et al., 2018). Here, HTRA1 is linked to preeclampsia.