NLRP3 and Alzheimer disease: Among the various inflammasomes, NLR pyrin domain containing 3 (NLRP3) inflammasome was the most widely studied and it has been regarded as a regulator of neuroinflammation in several central nervous system (CNS) disorders like Alzheimer’s disease (AD), Huntington’s disease, and pneumococcal meningitis (Jha et al., 2010; Hoegen et al., 2011; Tan et al., 2013; Zhou et al., 2016).