TNF and ankylosing spondylitis: Tumor necrosis factor (TNF) blockers have a high efficacy in treating Ankylosing Spondylitis (AS), a study reported that IgG Galactosylation status combined with MYOM2 rs2294066 polymorphism (T allele in rs2294066 leads to MYOM2 overexpression) could precisely predicts anti-TNF response of AS, indicating that MYOM2 might associated with the pharmacology of TNF blockers [50].