In addition, shATAD3A and hypoxia-induced sorafenib resistantLM3 cells desensitized the HCC cells to sorafenib, resulting in a significant decrease in apoptotic index (Fig. 2i and Supplementary Fig. S2g-2 h), whereas ATAD3A overexpression augmented the sorafenib-induced cell death (Fig. 2j, k and Supplementary Fig. S2d, 2e). This evidence concerns the gene ATAD3A and hepatocellular carcinoma.