PRRT2 and early-onset autosomal dominant Alzheimer disease: For example, TRP pathway members, including proteins such as transient receptor potential cation channel subfamily V member 2, PKC, phosphatidylinositol 3-kinase, and insulin growth factor 1, are critical for the pathogenesis of several human diseases such as type-I diabetes, Alzheimer’s disease, cardiomyopathy, and myasthenia gravis syndrome (Nilius and Voets 2005; Nilius 2007; Akopian 2016).