However, it is important to note that the restricted upregulation of renal inner medullary α-ENaC during Ang II–induced hypertension may disagree with other report that all 3 ENaC subunits were similarly induced in both renal cortex and medulla in this model.49 The reason for this discrepancy is unclear at this moment but may be related to differences in experimental protocols or animal species (mouse versus rat). This evidence concerns the gene AGT and hypertensive disorder.