A well-studied representative of this type of transcription factors is the SREBP (sterol regulatory element-binding transcription factor), a crucial transcription factor governing cholesterol and fatty acid biosynthesis.34–37 Similarly, S1P also processes membrane-bound ATF6 (activating transcription factor 6) during ER stress response.38 Currently, no evidence is available to suggest involvement of SREBP or ATF6 in regulation of Ang II–induced hypertension. The gene discussed is ATF6; the disease is Hypertension.