ATF6 and hypertensive disorder: A well-studied representative of this type of transcription factors is the SREBP (sterol regulatory element-binding transcription factor), a crucial transcription factor governing cholesterol and fatty acid biosynthesis.34–37 Similarly, S1P also processes membrane-bound ATF6 (activating transcription factor 6) during ER stress response.38 Currently, no evidence is available to suggest involvement of SREBP or ATF6 in regulation of Ang II–induced hypertension.