While the researches focusing on the association between CHI3L1 gene and CVD were limited and yielded the negative results, a prospective study investigated 41 SNPs of CHI3L1 gene and CVD outcomes including all major vascular events, CVD death, all‐cause mortality, myocardial infarction and thromboembolic stroke. This evidence concerns the gene CHI3L1 and myocardial infarction.