IL1B and rotator cuff syndrome: SAS synovitis was associated with overexpression of proinflammatory cytokines, enzymes, and MMPs, which may have an important role in the pain mechanism and pathophysiology of rotator cuff tear.7, 10 Meanwhile, Gotoh et al.12noted that overexpression of IL‐1β in the GHJ synovium in patients with a rotator cuff tear and emphasized the pivotal role of synovial inflammation in modulating rotator cuff degeneration.