Variability in LD1group correlated with several features of the metabolic syndrome including insulin resistance (HOMA-IR), insulin homeostasis (insulin, C-peptide), NAFLD (Liver fat, GGT, ALAT), glucose control (fasting glucose, HbA1c) and obesity (waist circumference, BMI), high triglycerides, and low HDL-C (Fig 1c). This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.