JUN and hepatocellular carcinoma: MUC18 has been shown to induce translational initiation and transcriptional activation of c-Jun/c-Fos in hepatocellular carcinoma [16] and has been suggested as a potential therapeutic target in malignant rhabdoid tumors through induction of apoptosis by inactivating protein kinase B (PKB) or the serine/threonine-specific kinase (AKT) signaling pathway [17].