AHR and cancer: The facts that AhR rs2066853 polymorphism might affect the two-way biological process (activation or detoxification) of procarcinogens regulated by CYP1A1 enzyme suggest that the mutant allele (A) and genotype (AA and GA) of this polymorphism is possibly associated with the indeterminate (increased or decreased) susceptibility to cancer, which could be used to explain the negative results in meta-analysis.