AHR and acute leukemia: While the mutant genotypes (AA or GA) of AhR rs2066853 polymorphism conferred statistically significant higher risk of glioma [12], lung cancer [13], acute leukemia [30], and breast cancer [18], some previous studies found that subjects with the same mutant genotypes (AA or GA) of rs2066853 site were more prone to have reduced risk for lung cancer [22, 25] and breast cancer [20, 25].