Gene ontology revealed that the genes driving PLS1 (the component responsible for most of the covariance between transcription and glioma distribution) were most strongly associated with chromatin organization, a process perturbed by IDH mutations and critically involved in the pathogenesis of glioma (Suzuki et al., 2015; Reifenberger et al., 2017). This evidence concerns the gene PLS1 and central nervous system cancer.