GPT and chronic hepatitis B virus infection: ALT, alanine aminotransferase; BL, baseline; cccDNA, covalently closed circular DNA; CHB, chronic hepatitis B; Env, envelope; HBcrAg, HBV core-related antigen; iHBV-DNA, intrahepatic HBV-DNA; iHBV-RNA, intrahepatic HBV-RNA; LR, likelihood ratio; NPV, negative predictive value; NA, nucleos(t)ide analogue; OLP, overlapping peptides; PBMC, peripheral blood mononuclear cells; Pol, polymerase; PPV, positive predictive value; rho, Spearman’s correlation coefficient; Se, sensibility; Sp, specificity; ULN, upper limit of normal; W12, week 12; W48, week 48.