Examination of the relationship between PI and immune cell infiltration to determine if these risk genes precisely reflect HNSCC immune environment revealed that lipid metabolism‐related genes PI negatively correlated with CD4+ T‐cells, CD8+ T‐cells, neutrophils cell, B‐cells, and dendritic cells (p = .002, p = .004, p = .025, p < .001, and p = .005; Figure 10). The gene discussed is CD8A; the disease is head and neck squamous cell carcinoma.