CST3 and hematocrit: Binary regression analysis was used to investigate the independent factors associated with END, and we found that cystatin C (OR 3.92, 95% CI 1.41–10.86, p = .009), HT (OR 4.87, 95% CI 1.60–14.85, p = .005), CHD (OR 10.37, 95% CI 2.48–43.31, p = .001), diastolic blood pressure at admission (OR 1.05, 95% CI 1.01–1.09, p = .007), NIHSS at admission (OR 1.05, 95% CI 1.01–1.09, p < .001), and PLR (OR 1.01, 95% CI 1.00–1.02, p = .006) were independently associated with END in CCE patients (Table 2).