The Cancer Genome Atlas performed a comprehensive genomic analysis of liver fluke‐negative and hepatitis‐negative ICC, and reported the presence of inactivating mutations in tumour suppressor genes ARID1A, ARID1B, TP53 and PTEN, and functional mutations in oncogenes IDH1/2, BRAF and KRAS.45 This evidence concerns the gene IDH1 and intrahepatic cholangiocarcinoma.