The total exome sequencing of 108 liver fluke‐associated tumours and 101 non‐liver fluke‐associated tumours revealed44 that the incidence of IDH1 or IDH2 mutations was higher in cases of ICC unrelated to hepatic fluke, which also led to the deletion of the tumour suppressor gene BAP1. This evidence concerns the gene IDH1 and intrahepatic cholangiocarcinoma.