Importantly, previous studies reported that AIFM3, LDHD, LYNX1, SCN2B or TMEM56 were all negatively corelated with glioma,32, 33, 34, 35, 36 and GINS1, KIFC1, NUF2, NUSAP1 or TPX2 were both positively related to glioma progression.37, 38, 39, 40, 41. Here, LDHD is linked to central nervous system cancer.