These authors used an in silico based approach to show that overexpression of SFRP4 is correlated with poor survival in glioma, colorectal, clear cell kidney, liver, head/neck SCC and bladder cancers but not breast, lung, pancreatic, ovarian or oesophageal cancer, suggesting disparate roles for this protein in different tumour contexts [26]. Here, SFRP4 is linked to carcinoma of esophagus.