However, moderate/high risk obesity was significantly more frequent in low CYP3A4 expressers than in normal expressers (13.6% of CYP3A4 low expressers, 1.5% of CYP3A4 normal/high expressers, OR = 13.5 [95%CL = 1.2–147.9], Wald ChiSq = 4.1, N = 87, P = 0.045). Here, CYP3A4 is linked to obesity due to melanocortin 4 receptor deficiency.