TP53 and cancer: Previously well-known molecular subtyping in GAC is TCGA subtypes23 and Asian Cancer Research Group (ACRG) subtypes24, in which TCGA typing is composed of Epstein Barr Vims positive, MSI, genomically stable (GS) and chromosomal instability (CIN), while ACRG contains MSI, MSS/EMT, MSS/TP53 + and MSS/TP53-.