To identify AURKA and AURKB interaction pathways in ALL pathogenesis, a PPI network was constructed, which could evidence the presence of both, and their participation in protein expression modulation of essential pathways for cellular organization during division, highlighting the mitotic cell cycle pathway and spindle control that appears with high correlation in this interaction pathway, demonstrating the importance of these proteins in mitotic organization. The gene discussed is AURKB; the disease is acute lymphoblastic leukemia.