CD40LG and systemic lupus erythematosus: The cell frequencies of CD154+IFN-γ+ and CD154+IL-10+ autoreactive Tcons positively correlated with disease activity (systemic lupus erythematosus disease activity index, SLEDAI, n = 14), as determined by Spearman’s rank correlation coefficients (r = 0.57, p = 0.03 and r = 0.63, p = 0.02, respectively, Fig. 2c).