Our candidate-gene association study involving individual analysis of four GWAS datasets (containing total of 2882 cases and 4397 controls) found 30% to threefold increased risk of breast cancer (OR 1.30 with rs2228528 in WHI to OR 2.91 with rs3750751 in CGEMS) conferred by six ERCC6 variations. This evidence concerns the gene ERCC6 and breast cancer.