Low-penetrance [RR or odds ratio (OR) < 3] genes, such as FGFR2, CASP8, MAP3K1 and LSP1, with MAF of about 30% in the general population and accounting for about 15% of inherited breast cancer cases have also been identified through genome-wide association studies (GWAS)7. This evidence concerns the gene FGFR2 and breast carcinoma.