To date, many studies on kidney stones have suggested that kidney stones have a significant impact on the occurrence and development of kidney cysts, kidney cancer and other kidney diseases; research has also partly revealed that the formation and development of kidney stones and calcium reactive oxygen species (ROS) and other transport metabolism are closely related and has also proven that intracellular IL-2R, p38 and Wnt signalling pathway activation and the occurrence of kidney stones have a potential link2–4. The gene discussed is IL2RA; the disease is nephrolithiasis.