Morphologic and immunophenotypic high grade gliomas (HGG) developed at low penetrance in both H3.3K27M/Trp53+/− and H3.3K27M/Trp53−/− mice, but not in H3.3K27M, Trp53+/− or Trp53−/− mice (Fig. 1b, c and Supplementary Fig. S2c, Supplementary Data 2). Here, TP53 is linked to glioma.