PDGFRA and neoplasm: Intriguingly, in another mouse model where H3.3K27M accelerated development of Trp53KO/Pdgfra-driven HGG17, the addition of H3.3K27M epigenetically activated RAS target genes compared to the H3.3WT HGG despite the pathway already being activated by constitutively active PDGFRA (Supplementary Fig. S6e, f)17 suggesting epigenetic mechanisms of pathway activation may play a role, even in mutant tumours.