CLOCK and metabolic dysfunction-associated steatotic liver disease: XBP1s transcriptionally regulates the hepatic 12-h clock to coordinate liver glucose and lipid homeostasis, but more causal links between the 12-h clock and NAFLD susceptibility, including detailed characterizations of the 12-h clock and its harmonics with the 24-h clock in other conditions, e.g., prolonged constant darkness, feeding or behavior changes that disrupt the 12/24-h rhythmicity, and exploration of additional 12-h clock regulators in central and peripheral systems remain to be investigated.