Accordingly, it has been shown that SCD1, LPCAT3, and LCAT activity correlates with membrane saturation23,54,64–66, wherein elevated ER stress was observed upon loss of either SCD1 or LPCAT3 activity23,54,64, and was associated with an increased level of LCAT in animal models of either obesity or overnutrition65,66. Here, SCD is linked to obesity due to melanocortin 4 receptor deficiency.