It has been reported that CD8+ T cell decline by SARS-CoV-2 infection is related to a poor prognosis and systemic inflammation in patients with COVID-19.21 Our results provide the evidence that CD147 mediates infection of SARS-CoV-2 in CD4+ and CD8+ T cells, exerting significant impacts on the prognosis of patients. Here, BSG is linked to COVID-19.