CD147 is reported to enter the cells through clathrin-independent endocytosis.24,25 Rab5 is a crucial regulator of endocytosis and locates at early endosome.26 In our study, the co-localization of CD147, spike, and Rab5 was detected in BHK-21-CD147 cells and lung tissues from patient with COVID-19 (Fig. 6b), indicating that the receptor CD147 and virions were endocytosed and located at the early endosome. This evidence concerns the gene RAB5A and COVID-19.