However, in mice with both loss of Kmt2d and deregulated Bcl2 expression, lymphoma incidence increased from 44.4% (12/27) in wild-type mice to 62.5% (15/24) in heterozygous mice and 78.6% (22/28) in homozygous mice, with cases ranging from early FL to DLBCL98. This evidence concerns the gene KMT2D and lymphoma.