BCL2 and lymphoma: And, fourth, the co-expression of MYC and BCL2 (two proto-oncogenes strongly associated with aggressive lymphomas) is more likely in advanced-stage DLBCL and is independently associated with a worse prognosis36 (UpToDate 4, https://www.uptodate.com/contents/prognosis-of-diffuse-large-b-cell-lymphoma).