Of the 150 genetic drivers of DLBCL described by Reddy et al., 21 (i.e., 14%) of them fit this description (#1 MLL2; #4 HIST1H1E; #6 CREBBP; #10 ARID1A; #15 ARID1B; #16 SETD1B; #18 SMARCA4; #33 SETD2; #34 TET2; #37 ARID5B; #38 EZH2; #43 EP300; #44 MLL3; #54 INO80; #55 CHD8; #58 DNMT3A; #71 NCOR1; #75 CHD1; #88 SETD5; #115 DICER1; #128 HIST1H2BC)73. This evidence concerns the gene EP300 and diffuse large B-cell lymphoma.