This subset of genes is skewed toward the top of the list, with 18/21 (86%) located in the “top 75,” 7/21 (33%) in the “top 20,” and 4/21 (19%) in the “top 10,” including the #1 most commonly altered gene in DLBCL: MLL2 (alternative name for KMT2D (lysine methyltransferase 2D)). This evidence concerns the gene KMT2D and diffuse large B-cell lymphoma.