KMT2D and lymphoma: Lastly, the extent to which Kmt2d loss directly influences lymphoma incidence and pathogenesis was tested in mice with wild-type, heterozygous-deleted, and homozygous-deleted Kmt2d. Similar to the findings of Zhang et al. and Jiang et al. in their studies of CREBBP93,96, deletion of Kmt2d alone was not enough to significantly increase lymphomagenesis (0/23 wild-type, 0/22 heterozygous-deleted, and 0/15 homozygous-deleted mice).