However, in mice with both a heterozygous Crebbp deletion and deregulated Bcl2 expression (which frequently co-occur in FL and DLBCL), there was a significant increase in lymphoma incidence, with 92% (22/24) of these mice developing some type of FL, compared to 61.5% (16/26) in mice with deregulated Bcl2 expression but wild-type Crebbp96. This evidence concerns the gene BCL2 and diffuse large B-cell lymphoma.