In line with commercial available HCC cells, UCK2 knockdown induced significant resistance on cytotoxic pyrimidine analogues and EGFR inhibitors in PDC-11# cells (Fig. S8A, B), whereas overexpression UCK2 in PDC-26# cells greatly sensitized to them (Fig. S8C, D). The gene discussed is UCK2; the disease is hepatocellular carcinoma.