Furthermore, through the utilization of pathway analysis we were also able to identify groups of proteins that were functionally linked to Ubqln2. By comparing results from multiple Ubqln2-dependent models of ALS, including both young and old animals, we were able to focus our analysis on a select group of proteins that were commonly altered upon different forms of Ubqln2 perturbation and to assess their relationship to UBQLN2. The gene discussed is UBQLN2; the disease is amyotrophic lateral sclerosis.