AKT1 and cancer: Furthermore, Wnt/β-catenin signaling orchestrates multiple cell signaling cascades, such as epidermal growth factor receptor (EGFR), Hippo/YAP, nuclear factor kappa-B (NF-κB), Notch, Sonic Hedgehog and PI3K/Akt pathway, which contribute to pivotal molecular mechanism in cancer development [19–24].