They include TP53 [6], PTEN [7], RB1 [6], CCNE1 [6, 8, 9], and HER2. Besides, proline-rich protein 11 (PRR11) has been newly identified as a novel oncogene in lung cancer [10], tongue squamous cell carcinoma [11], and pancreatic cancer [12]. The gene discussed is PRR11; the disease is familial pancreatic carcinoma.