Univariate analysis identified EZH2 expression, age, T stage, lymph node metastasis, distant metastasis, TNM classification, and tumor recurrence as independent prognostic factors of OS in patients with LUAD (log-rank test, P = 0.041, 0.026, < 0.01, < 0.01, 0.038, < 0.01, and < 0.01, respectively; Table 2). Here, EZH2 is linked to metastatic malignant neoplasm in the lymph nodes.