Interestingly, in a mouse model, tegafur-uracil and the metabolites of 5-FU and γ-hydroxybutyric acid significantly inhibit vascular endothelial growth factor (VEGF) mediated angiogenesis induced by many human cancer cell lines [21, 22] and VEGF mediated angiogenesis correlates with tumor vessel invasion in NSCLC [23]. This evidence concerns the gene VEGFA and cancer.