GOT1 and familial pancreatic carcinoma: Interestingly, recent data noticed that NRF2 mediated glutamine metabolism was closely associated with chemo-resistance in pancreatic cancers [40], given that GOT1 served as a crucial regulator for glutamate metabolism, we hypothesized that there might exist connections between NRF2 and GOT1 in regulating cisplatin-resistance in NSCLC.