Consistently, as shown in Fig. 3g, downregulated hsa_circRNA_103809 aggravated the promoting effects of cisplatin-induced cell apoptosis in CR-NSCLC cells, which were also reversed by knocking down miR-337-3p and overexpressing GOT1 (Fold changes: Cis + KD-circ+KD-miR and Cis + KD-circ+OE-GOT1 vs. Cis + KD-circ, 0.19 and 0.21 in A549/DDP; 0.32 and 0.33 in H1299/DDP; 0.46 and 0.35 in Calu-3/DDP. This evidence concerns the gene GOT1 and non-small cell lung carcinoma.