Based on the published literatures, by conducting in vitro and in vivo experiments, this study identified that the hsa_circRNA_103809/miR-377-3p/GOT1 pathway regulated cisplatin-resistance in NSCLC cells, and targeting this pathway improved cisplatin-sensitivity in NSCLC, which provided potential avenues for improving NSCLC treatment in the clinic. This evidence concerns the gene GOT1 and non-small cell lung carcinoma.