Furthermore, we conducted Annexin V-FITC/PI double staining assay to determine cell apoptosis, and the results indicated that cisplatin significantly increased cell apoptosis ratio in CS-NSCLC cells, which were reversed by overexpressing hsa_circRNA_103809 (Fold changes: Cis + OE-circ+OE-miR and Cis + OE-circ+KD-GOT1 vs. Cis + OE-circ, 4.66 and 2.27 in A549; 4.76 and 6.58 in H1299; 8.66 and 6.03 in Calu-3. This evidence concerns the gene ANXA5 and non-small cell lung carcinoma.