TREM1 and Sepsis: Given that M3 was successful in improving cardiac function in neonatal sepsis, we aimed to further identify if this impact was, in part, due to the eCIRP/TREM-1 interaction in cardiomyocytes or if it was merely a reflection of reduced sepsis severity seen with eCIRP inhibition in previous preclinical sepsis models (Qiang 2013; Denning et al. 2019).